free downlaod Biopython

http://en.wikipedia.org/wiki/Biopython
ioRuby Ruby language toolkit Website Platform License Open Bioinformatics Foundation
caCORE ontologic representation environment Website - Articles Platform License National Cancer Institute
caArray ontologic representation environment [1] - [2] Platform License National Cancer Institute
Integrated Genome Browser Java-based desktop genome browser Website Linux, Mac OS X, Windows CPL 1.0 GenoViz
IntAct molecular interaction database Website - Articles Platform License European Bioinformatics Institute
Java Treeview microarray data viewer Website - Articles Cross-platform License Developer
LabKey Server platform for integrating, analyzing and sharing data Website Linux, Mac OS X, Windows Apache License LabKey Software Foundation
UGENE integrated bioinformatics tools Website - Podcast Linux, Mac OS X, Windows GPL2 License Unipro